Molecular basis of Staphylococcus epidermidis infections

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Molecular & phenotypic characterization of Staphylococcus epidermidis in implant related infections

BACKGROUND & OBJECTIVES The discrimination between the Staphylococcus epidermidis colonizing the deep seated indwelling devices and those which are mere commensals has always been a challenge for the clinical microbiologist. This study was aimed to characterize the S. epidermidis isolates obtained from device related infection for their phenotypic and molecular markers of virulence and to see w...

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Staphylococcus epidermidis in Biomaterial-Associated Infections

T.F. Moriarty et al. (eds.), Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies, DOI 10.1007/978-1-4614-1031-7_2, © Springer Science+Business Media New York 2013 Abstract Coagulase-negative staphylococci, mainly Staphylococcus epidermidis , are currently the most frequent cause of hospital acquired infections in the USA. Mostly, but not exclusively, S. epiderm...

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Structural basis of Staphylococcus epidermidis biofilm formation: mechanisms and molecular interactions

Staphylococcus epidermidis is a usually harmless commensal bacterium highly abundant on the human skin. Under defined predisposing conditions, most importantly implantation of a medical device, S. epidermidis, however, can switch from a colonizing to an invasive life style. The emergence of S. epidermidis as an opportunistic pathogen is closely linked to the biofilm forming capability of the sp...

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Host Response to Staphylococcus epidermidis Colonization and Infections

The majority of research in the Staphylococcus field has been dedicated to the understanding of Staphylococcus aureus infections. In contrast, there is limited information on infections by coagulase-negative Staphylococci (CoNS) and how the host responds to them. S. epidermidis, a member of the coagulase-negative Staphylococci, is an important commensal organism of the human skin and mucous mem...

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Furanones, potential agents for preventing Staphylococcus epidermidis biofilm infections?

OBJECTIVES Staphylococcus epidermidis is often associated with biofilm infections related to medical implants. The aim of the present study was to find furanones that decrease biofilm formation without irritative or genotoxic effects, or effects on S. epidermidis growth. METHODS After screening including bioluminescence and biofilm assays, 2 furanones out of 11 were chosen for further studies...

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ژورنال

عنوان ژورنال: Seminars in Immunopathology

سال: 2011

ISSN: 1863-2297,1863-2300

DOI: 10.1007/s00281-011-0296-2